Synthesis, Physico-chemical, Spectral and Hypoglycemic Activity of Samarium Complex of Glimepiride, An Oral Antidiabetic Drug

This paper deals with the synthesis and characterization of a glimepiride-samarium complex a rare earth’s metal. Glimepiride is an oral hypoglycemic agent. The conductometric titrations were conducted using monovariation method which shows the ligand metal ratio as 2:1. Molar conductance value indicate that complex is non-ionic in nature. Analytical results agree to the molecular formula (C24H34N4O5S)2 Sm.4H2O. Rare earth’s element Sm shows the high coordination sites. The structure of the complex was assigned as hexagonal in which ligand moleculas joining the central Sm(III) atom with nH2O molecules. Infrared spectral studies have supported coordination of sulphonyl oxygen on one side and enolic oxygen attached from other side and four water molecule attached by four co-ordination sides with the samarium ion. Mass spectral and nuclear magnetic resonance studies of the complex proposed structure of the complex on the basis of analytical data.